Butyrolactone I
CAS No. 87414-49-1
Butyrolactone I ( Olomoucin )
Catalog No. M27807 CAS No. 87414-49-1
Butyrolactone I is an ATP-competitive inhibitor of CDK and cdc2 kinase family.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 402 | Get Quote |
|
10MG | 581 | Get Quote |
|
100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameButyrolactone I
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NoteResearch use only, not for human use.
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Brief DescriptionButyrolactone I is an ATP-competitive inhibitor of CDK and cdc2 kinase family.
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DescriptionButyrolactone I is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines.(In Vitro):Butyrolactone I (70 and 100 μM) increases the percentage of DU145 cells in the 4C phase of the cell cycle. Butyrolactone I increases the amount of cyclin B1 positive cells in the 4C phase on day 1 and returns to normal by day 3. Butyrolactone I inhibits Cdc2 of unsynchronized cultured prostate cancer cells and interrupts the cell cycle progression toward cell division. The Butyrolactone I inhibition of Cdc2 led to the accumulation of cells in the 4C phase without mitosis resulting in an accumulation of cyclin B1.
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SynonymsOlomoucin
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PathwayAngiogenesis
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TargetCDK
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number87414-49-1
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Formula Weight424.4
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Molecular FormulaC24H24O7
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Purity>98% (HPLC)
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Solubility——
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SMILESC([C@]1(C(OC)=O)C(=C(O)C(=O)O1)C2=CC=C(O)C=C2)C3=CC(CC=C(C)C)=C(O)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Davila-Gutierrez CE, et al. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. Am J Trop Med Hyg. 2002 Mar;66(3):251-4.
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